The article presents a curated list of 50 prominent actors and actresses in their first movie roles, highlighting their early career beginnings. Each entry includes the actor’s name, the title and release year of their debut film, the production studio, and a brief description of their role or the film’s premise. The list spans decades, showcasing a mix of well-known and obscure debuts across various genres. Notable examples include Zendaya in the 2012 Disney TV movie *Frenemies*, portraying a young magazine editor opposite Bella Thorne. Dakota Fanning appeared in the 2001 comedy *Tomcats* in a minor role, signaling her early career. Taraji P. Henson debuted in the 1998 crime thriller *Streetwise*, set in Washington D.C.’s drug underworld. Chris Hemsworth’s first film role was as George Kirk in the 2009 *Star Trek* reboot, predating his Marvel fame. Similarly, Chris Pine’s initial role was in *The Princess Diaries 2: Royal Engagement* (2004), while Anne Hathaway gained recognition in the original *Princess Diaries* (2001). The list features actors who started in TV movies, such as Angelina Jolie in the 1982 film *Lookin’ to Get Out*, which also starred her father, Jon Voight, and Jennifer Aniston in the 1990 TV film *Camp Cucamonga*. Others transitioned from television to film, like Selena Gomez, who made her debut in the 2003 spy comedy *Spy Kids 3-D: Game Over* at age 11. Some debuts were in niche or indie projects. Saoirse Ronan starred in the 2007 romantic comedy *I Could Never Be Your Woman* with Michelle Pfeiffer, while Margot Robbie acted in the 2008 Australian crime drama *Vigilante*. Cara Delevingne’s screen debut came in the 2012 adaptation *Anna Karenina*, and Kristen Stewart’s first major role was in the 2001 drama *The Safety of Objects*. The list also includes international debuts, such as Penelope Cruz in the 1992 Spanish romantic drama *Jamón, Jamón* and Nicole Kidman in the 1983 Australian TV movie *Skin Deep*. Several actors began in musical or theater-related films, like Anna Kendrick in the 2003 film *Camp* and Demi Lovato in 2008’s *Camp Rock*. The article underscores the diversity of pathways into the film industry, ranging from blockbuster franchises to obscure projects, and highlights how early roles—though varied in prominence—served as foundational steps for many successful careers. It is structured as a retrospective exploration of how these actors’ trajectories began, offering insight into the breadth of their early experiences.